The Scream star reached the milestone on Saturday (08Sep12) and to celebrate, he headed out with his loved ones to BOA Steakhouse.
Arquette was all smiles as he arrived at the eaterie with daughter Coco, eight, and the pair was joined by the actor's sister Patricia.
The actress took to Twitter.com to wish her sibling all the best on his big day, writing, "Happy birthday davidarquette You are such an amazing brother! Love you so!!", prompting the birthday boy to reply: "thank you sweetie".
He later reached out to his online fans, adding, "Thanks to all the new birthday twitter followers!", while his ex Courteney Cox declared, "Happy birthday DA. No one should be celebrated more than you!"