The Knocked Up filmmaker will follow in the footsteps of previous recipients Bradley Cooper, Zach Galifianakis and Ben Stiller on 22 October (12) when he picks up the Hollywood Comedy Award at a gala in California.
Meanwhile, child star Quvenzhane Wallis, who wowed critics with her performance in drama Beasts of the Southern Wild, will be presented with the New Hollywood accolade and The Sessions' John Hawkes will receive the Hollywood Breakout Performance Award.
The Hollywood Cinematographer Award will go to Wally Pfister for his work on The Dark Knight Rises. It will be his second honour for his work on a Christopher Nolan project - he previously won the same prize for Inception.
The Avengers' visual effects supervisors will also be honoured for their artwork, according to The Hollywood Reporter.
Last week (ends07Sep12), it was announced Chris Pine's upcoming adventure movie Rise of the Guardians would be feted with the Hollywood Animation Award.