Ryder landed her big break playing kooky teenager Lydia Deetz in Burton's huge hit Beetlejuice in 1988 and went on to appear in Edward Scissorhands and the filmmaker's latest project, Frankenweenie.
The star is adamant her huge success as an actress is down to her friendship with the quirky director.
She tells FlicksandBits.com, "I've known Tim Burton for 25 years, and I credit him with my career. I really mean that.
"(At the Beetlejuice audition) this guy came in and started talking about movies and music, and 25 minutes later I was like, 'When is this Tim Burton guy coming?' And he was like, 'That's me!'
"And I was like, 'Oh!' I had no idea that a director could actually be so cool and I could easily hang out with them, you know?"
"Tim has always been a very special person to me, I love being around him, it never feels like work. Our relationship, in a very strange way, it's the same... that love is still there. It's the same Tim Burton from that wonderful day."