The actor's wife, writer Victoria Vantoch, has given birth to the couple's second child, a baby girl, according to a post on the U.S. TV drama's official Twitter.com page.
A message reads, "Supernatural star @mishacollins and wife Victoria Vantoch welcomed their 2nd baby into the world-and it's a girl! Congratulations!"
The tot's name has not yet been revealed, but she will be a little sister for the stars' two-year-old son West Anaximander.
The couple wed in 2002.