To make matters worse, the slip-up has happened before.
And, as if that wasn't bad enough, the Kangaroo Jack star has previously confessed to having a major crush on his co-star, Tempestt Bledsoe.
The TV couple appeared on U.S. news show Access Hollywood Live on Wednesday (03Oct12) and Anderson attempted to explain himself.
He said, "Last night at our taping I accidentally stuck my tongue in her throat - this is the second time that it's happened.
"In my defence it was during a kissing scene... It didn't dawn on me until I was driving home... and I was like, 'Oh my God, Tempestt is gonna sue me!'"
Former The Cosby Show star Bledsoe joked, "Men are never aware of where their tongues are gonna go. They have no control over them. I understand that."
The slip-up could land Anderson in trouble with his real wife - because he confessed he had yet to tell her about the misplaced tongue.
Looking worried when he was asked if his wife Alvina would be OK with his honest mistake, he said, "I'll know when I get home. She's watching right now."