The late British writer's life will be commemorated with the memorial, which will be placed on the wall of a building at the University of Manchester, where he studied English literature from 1937 to 1940.
Burgess went on to write 33 novels, including his most famous work, 1962's A Clockwork Orange, which was made into a hugely controversial film starring Malcolm McDowell in 1971.
Dr Andrew Biswell, director of the International Anthony Burgess Foundation, says, "I'm delighted that the university has decided to install the first British public monument to Burgess, 50 years after A Clockwork Orange was first published."
Burgess died in 1993. The plaque will be unveiled on Thursday (11Oct12).