The silent film star will celebrate her latest milestone on 20 October (12) at the Cinefamily Silent Film House Theater in Hollywood, where invited guests will be treated to a screening of clips from the actress' lengthy career, which began alongside Lon Chaney in 1925's Phantom Of The Opera.
Laemmle made movie history when she became one of the first stars to speak in a film - the actress spoke the first lines in Bela Lugosi's classic Dracula.
Guests will also get a sneak peek at her latest role in web series Broken Dreams Blvd, starring Danny Aiello.
In the series, she plays a grandmother who runs the oldest tour bus company on Hollywood Boulevard.
Laemmle's family played a big part in the history of Hollywood - her uncle, Carl Laemmle, not only founded Universal Studios but also created the Hollywood tourism trade.
Aiello, actresses Renee Taylor and Fran Drescher, The Hulk Lou Ferrigno and relatives of silver screen greats Bella Lugosi and Tyrone Power are expected to attend the birthday party.