The Anchorman star was diagnosed with breast cancer and lost her ex-boyfriend to a drug overdose within months of each other - and she still can't believe her bad luck.
She tells More magazine, "Both of my cats died right after I found out I had cancer. The cats and the boyfriend died, all within three months. I laugh but... oh my God!"
Applegate dumped aspiring photographer Lee Grivas shortly after learning she was battling cancer because she decided she couldn't look after a drug addict and herself.
She has since become a mum to a baby girl named Sadie and is engaged to wed the tot's father, musician Martyn LeNoble.