The Hollywood Foreign Press Association will honour the actress/director for her contributions to showbusiness at the group's 70th awards ceremony on 13 January (13).
Foster's Panic Room co-star Kristen Stewart and actor Simon Baker made the announcement at the Beverly Hills Hotel on Thursday morning (01Nov12).
The 49 year old, who already has two Golden Globes for her performances in The Accused and The Silence of the Lambs, will be the youngest celebrity to be feted with the trophy since Charlton Heston in 1967.
The Cecil B. DeMille Award is given to individuals who have made an impact on entertainment. Previous recipients have included Morgan Freeman, Bette Davis, Harrison Ford, Audrey Hepburn, Robert De Niro, Al Pacino, Martin Scorsese and Steven Spielberg.