The Titanic star turned 38 on Sunday (11Nov12), and he celebrated by hosting a bash at Manhattan hotspot The Darby on Saturday night (10Nov12).
DiCaprio partied with famous pals including Beyonce and her husband Jay-Z, as well as longtime movie collaborator Martin Scorsese, his The Wolf of Wall Street co-star Jonah Hill, Harry Potter's Emma Watson, and actor Jamie Foxx.
Other guests included Mark Ruffalo, Edward Norton, Chris Rock and Busta Rhymes, while the evening featured musical performances from Gary Clark, Jr., jazz guitarist Django Reinhardt and pianist Eric Lewis.
The Hollywood star showed his charitable side by using the party to raise money for a good cause by adding a fee to every bottle of booze sold.
A $500,000 donation was made to the American Red Cross, according to New York Post gossip column Page Six.