The 19 year old, who has played Sheen's onscreen nephew since the series launched in 2003, urged fans to quit watching his show's "filth" for their own good in a taped testimony for the Forerunner Christian Church.
Jones told how his Christian faith and Bible studies had led him to despise his job, insisting, "I'm on Two and a Half Men and I don't want to be on it."
The teenager has since apologised to his colleagues for the remarks, but Sheen, who was fired from the series in March last year (11), has likened Jones' tirade to the Heaven's Gate cult which believed the 1995 comet Hale-Bopp would save them from the end of the world.
He tells People.com, "With Angus' Hale-Bopp-like meltdown, it is radically clear to me that the show is cursed."
Sheen was sacked from the hit TV show after feuding with producers, and Hollywood actor Ashton Kutcher stepped in to fill the void.