The Salt star and her fiance Brad Pitt are parents to a brood of six: Maddox, 11; Pax, nine; Zahara, seven; Shiloh, six, and twins Knox and Vivienne, four - and Jolie admits she is thinking about becoming a full-time mum within the next decade because she won't be able to juggle her career with her parenting duties and her extensive charity work.
She tells England's Channel 4 News, "I think I'm going to have to give up the acting as the kids hit the teenage years... (there will be) too much to manage at home.
"I have enjoyed being an actress. I am so grateful to the job and I have had great experiences and I have even been able to tell stories and be a part of stories that mattered and I have done things for fun. But if it went away tomorrow I would be very happy to be home with the children."
The news comes just months after 48-year-old Pitt announced he was planning to retire when he hits 50.
He told U.K. publication The Sunday Times' Culture magazine, "We all have a shelf life, and mine is coming."