The Oscar-winning actress became a first-time mother last summer (12), and subsequently put her movie career on hold, postponing work on a film project called Black Wings Has My Angel with Tom Hiddleston.
However, X-Men director Bryan Singer has now revealed Paquin has agreed to reprise her role as Rogue in his new blockbuster X-Men: Days of Future Past.
Ellen Page, who appeared in X-Men: The Last Stand, and Shawn Ashmore will also return to the franchise in the new film alongside regulars Hugh Jackman, Sir Patrick Stewart and Sir Ian McKellen.
Singer announced the casting news in a post on his Twitter.com page, writing, "Very excited to welcome Anna Paquin, Ellen Page & Shawn Ashmore to X-Men: Days of Future Past - thank you (X-Men: The Last Stand director) Brett Ratner for letting them live!"
The original castmembers will be joined by X-Men: First Class stars James McAvoy and Michael Fassbender, who played younger versions of Stewart and McKellen's characters, as well as Jennifer Lawrence and her rumoured ex-boyfriend Nicholas Hoult, who met on the set of the superhero sequel.