The star has racked up more than 40 film credits since making her acting debut at 14, and had to tackle music critics' bias when she decided to form her own rock band, Juliette and the Licks.
But Lewis is adamant acting is hard work, citing one particularly harrowing stunt she completed in a field of rattlesnakes while shooting Oliver Stone's 1994 action movie Natural Born Killers.
Speaking on Britain's Live from Studio Five, she recalls, "That movie was a blast to do. It was very strange. It's funny because people have all these pre-conceived notions 'cause I come from film so they think I'm gonna be pampered and precious and a diva coming into music. It couldn't be more opposite because the kinds of movies I've done have all been really interesting, rough shoots. Very long hours, very strange environments.
"For instance (in Natural Born Killers), I remember walking through rattlesnakes. They were live rattlesnakes, and me and Woody (Harrelson) walked through them. The camera guy, just to put it in perspective, he said he wasn't going to do it. He told Oliver, 'I'm out, I'm out!' Me and Woody were like, 'Oh no.'
"There's a rattlesnake wrangler, he's like, 'Don't worry. They're cold. When they're cold they won't attack you 'cause they're curled up!' But me and Woody, we were up for it."