The hit show, starring Brits Alfred Molina and Eddie Redmayne, picked up five awards at New York's Radio City Music Hall.
Bon Jovi star David Bryan's Memphis was also the toast of Broadway, picking up four awards - including the night's Best Musical honour. Fela! and La Cage aux Folles claimed only three of their 11 nominations each.
Onstage husband and wife Denzel Washington and Viola Davis were big winners, claiming the night's Best Actor and Actress prizes for a Play for Fences, which was also named Best Revival. Scarlett Johansson was a first-time Tony Awards winner for her Broadway debut in A View From The Bridge and Catherine Zeta-Jones was named Best Actress in a Musical.
Green Day's American Idiot was a double winner.
There were also special awards for British playwright Alan Ayckbourn and actors Marian Seldes and David Hyde Pierce.
The show was a true celebration of all things musical and theatrical with highlights including a show-stopping performance by Glee stars Matthew Morrison and Lea Michele, a dramatic rendition of Send in the Clowns by Zeta-Jones and stunning segments from hit musicals Fela! and La Cage aux Folles.
Green Day helped give the big show a rocking start as they performed two songs from their American Idiot musical.
It was couple's night in the audience with Johansson joined by husband Ryan Reynolds, Michael Douglas supporting his wife Zeta-Jones and Will Smith and Jada Pinkett Smith and Antonio Banderas and Melanie Griffith turning out.
Even Jay-Z, who had performed at the Bonnaroo festival in Tennessee on Saturday (12Jun10), and his wife Beyonce dressed it up for a night at the theatre awards.
Host Sean Hayes was perfect, cracking jokes at the expense of some of his movie star audience members and dressing up as both Annie and Spider-Man for added laughs.
The 2010 Tony Award winners are:
Best Performance by a Featured Actress in a Play - Scarlett Johansson (A View From The Bridge)
Best Performance by a Featured Actor in a Play - Eddie Redmayne (Red)
Best Direction of a Play - Michael Grandage (Red)
Best Direction of a Musical - Terry Johnson (La Cage aux Folles)
Best Performance by a Featured Actress in a Musical - Katie Finneran (Promises, Promises)
Best Performance by a Featured Actor in a Musical - Levi Kreis (Million Dollar Quartet)
Best Costume Design of a Play - Catherine Zuber (The Royal Family)
Best Costume Design of a Musical - Marina Draghici (Fela!)
Best Lighting Design of a Musical - Kevin Adams (American Idiot)
Best Scenic Design of a Play - Christopher Oram (Red)
Best Scenic Design of a Musical - Christine Jones (American Idiot)
Best Lighting Design of a Play - Adam Cork (Red)
Best Sound Design of a Musical - Robert Kaplowitz (Fela!)
Best Performance by a Leading Lady in a Play - Viola Davis (Fences)
Best Performance by a Leading Man in a Play - Denzel Washington (Fences)
Lifetime Achievement Award - Alan Ayckbourn
Lifetime Achievement Award - Marian Seldes
Isabelle Stephenson Award - David Hyde Pierce
Best Orchestrations - David Bryan & Daryl Waters (Memphis)
Best Original Score - David Bryan & Joe DiPietro (Memphis)
Best Book of a Musical - Joe DiPietro (Memphis)
Best Choreography - Bill T. Jones (Fela!)
Best Revival of a Play - Fences
Best Play - Red
Best Revival of a Musical - La Cage aux Folles
Best Performance by a Leading Actress in a Musical - Catherine Zeta-Jones (A Little Night Music)
Best Performance by a Leading Actor in a Musical - Douglas Hodge (La Cage aux Folles)
Best Musical - Memphis.