The innovative epic triumphed in categories including Best Science Fiction Film, Best Music and Best Special Effects, while Cameron took home the Best Director and Best Writing trophies, as well as The Visionary Award.
The movie's stars were also honoured at the event, held by the Academy of Science Fiction, Fantasy & Horror Films in Burbank, California. Sam Worthington and Zoe Saldana led the best actor categories and Sigourney Weaver was named Best Supporting Actress.
The other movies to claim trophies were Watchmen, Inglourious Basterds, District 9, Monsters vs. Aliens and Drag Me To Hell.
In the TV categories, mystery drama Lost led the way, claiming the Best Television Series and Best Actor on Television for Josh Holloway. Breaking Bad and Dexter also scored wins and last year's (09) recipient of the Life Career Award, Leonard Nimoy, was lauded for his guest appearance on Fringe.
This year's (10) Life Career Award was handed to director Irvin Kershner, according to Variety.com.