The comedienne was handed the trophy for Outstanding Talk Show: Entertainment at the ceremony for The Ellen DeGeneres Show.
But it was a disappointing night for General Hospital, the soap opera which James Franco joined for a brief stint last year (09), the show only landed two prizes despite scoring a massive 18 nominations.
Julie Berman was named Best Younger Actress in a Drama Series and the soap also won Best Drama Series Directing Team.
Meanwhile, soon-to-be-scrapped As The World Turns landed three awards.
The show picked up Best Lead Actress in a Drama Series (Maura West), Best Lead Actor in a Drama Series (Michael Park) and Top Supporting Actress in a Drama Series (Julie Pinson).
Other winners at the Las Vegas Hilton included The Bold & The Beautiful, which landed Best Drama Series and Drama Series Writing Team, while the show's star Drew Tyler Bell, picked up Best Younger Actor in a Drama Series.
Best Supporting Actor in a Drama Series was handed to Billy Miller for The Young and The Restless, while quiz show Cash Cab won two awards for Best Game Show and Game Show Host.