The former news anchor has teamed with biographer Andrew Morton for the memoir, tentatively titled I Love Your Work.
The book will detail his "successful recovery" following a string of highly-publicised stints in rehab, the last of which followed his dismissal as co-presenter of celebrity news show The Insider in 2008.
O'Brien tells the New York Post he will also address his 2004 divorce from wife Linda, and “my unfortunate scandal", referring to a series of slurred sexually graphic messages left on the voicemail box of an undisclosed female following the couple's split.
He says: "Not many people know what it's like to be in the middle of a firestorm that is a scandal and the personal insights and collateral damage offer valuable lessons to everybody."
The memoir is scheduled to hit shelves next autumn (11).