Norton launched Crowdrise.com to give individuals and organisations a platform to raise money for various causes and Rogen is using the site to raise $50,000 (£33,000) to help fight Alzheimer's disease.
And the funnyman, whose page features the headline, "Kick Alzheimer's in the a**", is delighted to have an "enjoyable" place to begin his fundraising efforts.
He tells Variety.com, "I'm all for anything that makes the idea of charity not lame and boring and very serious. Because I feel that that's what keeps a lot of young people away. I've found that people are a lot more receptive if you make it fun and enjoyable no matter how serious what you're trying to support is.
"Crowdrise is for people like me who are just beginning and not that smart. I can go on and easily navigate a way of seeing what other causes I might like to get into. That's the best thing about it - it's not directed at one specific cause. It's every cause."
Rogen's Knocked Up co-star Paul Rudd is also logging on - despite being an internet novice.
He adds: "I am kind of dumb because I don't have Facebook or Twitter or any of that stuff. And yet, I thought, 'God, Crowdrise makes total sense!' You can scroll around on Crowdrise and say, 'Oh, this person is involved in this.' It's like playing around on YouTube. I was kind of messing around and saw (singer) Glen Hansard is buying this truck for the Maasai. I'm learning about things that I would never know about."
Rudd is supporting the Our Time Theater Company, a charity that helps kids with speech problems.