Gaines has been tapped to take over as Miss Daisy's son, Boolie Werthan, in the latest stage version of the 1989 Oscar-winning film, about the relationship between an elderly Jewish woman and her African-American chauffeur.
The actor joins an all-star cast including fellow Tony-winners Vanessa Redgrave and James Earl Jones, whose respective characters Miss Daisy and chauffeur Hoke were played by Jessica Tandy and Morgan Freeman on the big screen.
Gaines has won four Tony Awards for acting, most recently for the latest revival of Gypsy; he also earned Tony gold for Contact, She Loves Me and The Heidi Chronicles.
Driving Miss Daisy originally opened Off-Broadway in 1987. The Broadway version is scheduled to begin 16 weeks of performances on 7 October (10).