The Oscar winner is mum to daughter Gaia and adopted son Tindyebwa with her actor husband Greg Wise and she admits she's been yearning to temporarily step away from the spotlight for some time.
She tells the Hollywood Reporter, "Next year, I'm going to take a sabbatical. I'm not going to fund raise or perform or travel, except in pursuit of new vistas with my family. I've been meaning to do this for a long, long time, but it's been like putting the brakes on a large ship because there is so much going on."
And she admits her longtime battle with "mild depression" has contributed to her decision to take an extended vacation.
Thompson says, "I find the job I do emotionally very demanding.
"I suffer from occasional mild depression, which I think is a very common thing... and it's a very much hidden thing people don't talk about. I think it should be discussed."