The wheelchair-bound 58 year old, who played decorator Otho in Tim Burton's hit film, banged his head in the fall - and that killed him, according to his sister Susan Gagne.
In a statement she says, "He was having mobility problems, and he was in a wheelchair. It looks like he fell and hit his head in the kitchen, and that's the cause of death."
Shadix was a regular in Burton films - he was among the cast of Planet of the Apes and voiced The Mayor in The Nightmare Before Christmas.
He retired from acting in 2006.