The actress played Jade in the first film and was slated to reprise her role in The Hangover 2, but Warner Brothers bosses have revealed she won't be joining Bradley Cooper, Zach Galifianakis, Justin Bartha, Ed Helms and Ken Jeong in the sequel.
A studio spokesman tells Eonline.com, "Unfortunately Heather won't be in the sequel; they way the story unfolds doesn't allow any room for her character to show up. I don't want to reveal to much of the film, but once you see it you'll understand."
The move will be a blow to Graham, who made it clear she was desperate to be a part of a sequel last year (09) - she told the website she'd like to play a pregnant stripper: "I think (Ed Helms' character) Stu should get her pregnant, and that she should do a pregnant strip dance. I know it sounds so wrong, but it sounds so right."
Meanwhile, cast member Sasha Barrese has started teasing fans about a very big "unbelievable" surprise guest: "It's the best cameo you've ever seen in your entire life. It's a guy. That's all I'm going to say. It's the best."
That guy could be Tiger Woods - director Todd Phillips announced he wanted the disgraced golfer for the sequel last year (09).
He told HollyScoop.com, "We are going to try and get Tiger Woods for the second one... and help him regain his image."