The legendary horror movie-maker directed the former couple in 1996's Scream and was delighted when they went on to marry and become parents to a daughter, Coco.
They announced this month (Oct10) that they are taking a break from their marriage and the separation occurred while they were onset with Craven filming Scream 4.
The director admits he had no idea the couple was no longer together during the shoot and he was devastated when he heard about the split.
He tells E! Online, "We didn't have any idea that was going on... (It) was a big love fest... It's very sad. I just about cried when I heard. It's a wrenching thing to happen to anybody that you love. I wish them both the best."