Cage, who was named a United Nations Goodwill Ambassador for Global Justice last year (09), spoke out at a conference aimed to boost support for a U.N. convention to curb organised crime in Vienna, Austria on Thursday (21Oct10).
The Oscar winner appealed to non-governmental organisation executives, judges, prosecutors, doctors and religious leaders to work together to eradicate the "highly contagious" problem.
He continued: "Organised crime is too big for communities or even states to confront on their own. States must work together... No part of the world is immune to trafficking and organised crime."
Calling for a change, Cage highlighted the growing crime rates in impoverished, lawless communities in which victims are often forced into prostitution, piracy or the army, while others become addicted to drugs or infected with HIV.
He said, "There are many kinds of victims of organised crime, and... children are among the most vulnerable."
The Leaving Las Vegas star also described his position as a goodwill ambassador as his "most challenging and meaningful role", admitting he even considered quitting Hollywood to devote his life to helping others.
But for now, he's happy to use his celebrity to raise awareness for worthy causes.
He added: "At some point I wanted to stop being an actor and start taking action."