Earlier reports suggested the 45-year-old actor was accompanied to a New York medical centre by his ex-wife Denise Richards, after cops were called to investigate an alleged disturbance in Sheen's room at the plush Plaza Hotel.
According to the New York Post, hotel security staff called police after discovering Sheen nude and his suite in shambles. Tables and chairs were reportedly thrown around the room and a chandelier damaged.
Sheen told officers he had been "out partying" and returned to the Plaza with a woman, but flew into a rage when he discovered his wallet was missing, according to the newspaper.
A New York Police Department spokesman has now confirmed an ambulance carried an "emotionally disturbed person" from New York's Plaza hotel to New York Downtown Hospital at 1:30am.
Sheen's rep, Stan Rosenfield, has failed to comment on details of the alleged disturbance but confirms his client remains in hospital.
He tells CNN: "What we are able to determine is that Charlie had an adverse allergic reaction to some medication and was taken to the hospital, where he is expected to be released tomorrow."
Late last year (09) Sheen was arrested in Aspen, Colorado after fighting with his now-estranged wife Brooke Mueller.