The star, who also appeared opposite Johnny Depp in Cry-Baby, was driving in Montgomery, New Jersey in June (10) when she struck another vehicle as it turned into a driveway.
Helene Seeman, a passenger in the front seat of the other car, was pronounced dead at the scene, while the driver, Fred Seeman, was airlifted to a nearby hospital with serious injuries.
Locane confessed to police she had had several glasses of wine before getting behind the wheel, reports TMZ.com.
She was formally charged by a grand jury in Somerset County on Thursday afternoon (16Dec10).
However, her attorney Blair Zwillman has vowed to challenge the aggravated manslaughter count, insisting: "I don't believe it is supported by the law or the facts and I think it constitutes over-reaching by the prosecutor's office."
If convicted, the actress faces a maximum of 30 years for the manslaughter charge and up to 10 years for the assault by auto count.