The actor will begin previews of Ghetto Klown at Manhattan's Lyceum Theater on 21 February (11).
The show chronicles the early days of Leguizamo's acting career.
The 46 year old star last appeared on Broadway in 2008 when he was part of the ensemble cast in a revival of American Buffalo. He also wrote and appeared in stage show Sexaholix from 2001 to 2003 and he won an Emmy for his monologue in 1998 Broadway comedy, Freak.
His latest show, directed by Fisher Stevens, officially opens for a 12-week run on 22 March (11).