Mendoza quit her role as villainess Arachne in Spiderman: Turn Off the Dark last week (ends02Jan11), a month after she was injured in an onstage accident which saw her hit on the head with a weighted rope.
The actress subsequently suffered nausea and headaches and took time off before quitting the troubled Broadway show altogether.
Director Julie Taymor has now announced Carpio as her official replacement and the actress will take Mendoza 's place in the show on Tuesday night (04Jan10).
Taymor, who previously directed Carpio in 2007 romance movie Across the Universe, tells the Hollywood Reporter, "T.V. is a superb singer and actress whom I've loved since we worked together on Across the Universe. She brings a unique talent and take on the role of Arachne... We are thrilled she is taking over the role."