Robert Pattinson and Kristen Stewart missed out on early honours as Johnny Depp won the Favourite Movie Actor a year after he was awarded the first Favourite Movie Actor of the Decade Award at the 2010 event.
Pattinson and Stewart also missed out on the Favourite Movie Star Under 25 Award - to Zac Efron.
But then the movie vampires took over, winning four big awards, including the night's Favourite Movie honour and Favourite Movie Actress (Stewart).
Eminem also claimed four big awards - for Favourite Male Artist and Favourite Hip-Hop Artist and for his Rihanna duet Love The Way You Lie, which was named Favourite Song and Favourite Music Video.
TV medical drama House was also a quadruple winner, taking home the Favourite TV Drama honour, while stars Hugh Laurie and Lisa Edelstein claimed the Favourite TV Drama Actor and Actress awards. Laurie was also named Favourite TV Doctor.
Other multiple winners included Katy Perry, who was named Favourite Female Artist and Favourite Online Sensation; TV hit Glee, which claimed the Favourite TV Comedy and Favourite TV Comedy Actress (Jane Lynch), and Adam Sandler, who picked up the Favourite Comedic Actor honour, while his 2010 movie Grown Ups landed the Favourite Comedy Movie accolade.
Tim Roth was also a surprise double winner, picking up the Favourite TV Crime Fighter award for his role in Lie To Me. The show also won the Favourite TV Crime Drama.
The full list of winners is:
Favourite Movie - The Twilight Saga: Eclipse
Favourite Drama Movie - The Twilight Saga: Eclipse
Favourite Onscreen Team - Robert Pattinson, Taylor Lautner and Kristen Stewart (The Twilight Saga: Eclipse)
Favourite Movie Actress - Kristen Stewart (The Twilight Saga: Eclipse)
Favourite Movie Actor - Johnny Depp
Favourite Comedic Star - Adam Sandler
Favourite Movie Star Under 25 - Zac Efron
Favourite Comedy Movie - Grown Ups
Favourite Action Movie - Iron Man 2
Favourite Action Star - Jackie Chan
Favourite Family Movie - Toy Story 3
Favourite Horror Movie - A Nightmare on Elm Street
Favourite TV Drama - House
Favourite TV Comedy - Glee
Favourite TV Comedy Actor - Neil Patrick Harris (How I Met Your Mother)
Favourite TV Comedy Actress - Jane Lynch (Glee)
Favourite TV Drama Actress - Lisa Edelstein (House)
Favourite TV Drama Actor - Hugh Laurie (House)
Favourite TV Obsession - Dexter
Favourite Sci-Fi/Fantasy Show - Fringe
Favourite New Drama - Hawaii Five-0
Favourite New TV Comedy - $#*! My Dad Says
Favourite TV Guilty Pleasure - Keeping Up With The Kardashians
Favourite Talk Show Host - Conan O'Brien
Favourite TV Guest Star - Demi Lovato (Grey's Anatomy)
Favourite TV Doctor - Hugh Laurie (House)
Favourite TV Family - The Simpsons
Favourite Family TV Movie - Camp Rock 2: The Final Jam
Favourite TV Chef - Rachael Ray
Favourite Competition Show - American Idol
Favourite TV Crime Drama - Lie To Me
Favourite TV Crime Fighter - Tim Roth (Lie To Me)
Favourite Rock Band - Paramore
Favourite Female Artist - Katy Perry
Favourite Country Artist - Taylor Swift
Favourite Male Artist - Eminem
Favourite Online Sensation - Katy Perry
Favourite Song - Love The Way You Lie by Eminem & Rihanna
Favourite Pop Artist - Rihanna
Favourite Breakout Artist - Selena Gomez & The Scene
Favourite R&B Artist - Usher
Favourite Hip-Hop Artist - Eminem
Favourite Music Video - Love The Way You Lie by Eminem & Rihanna