The Oscar winner co-founded the J/P HRO Haitian Relief Organization in the wake of the January 2010 earthquake and has spent months in the Caribbean nation helping to distribute food and medical supplies, as well as build schools and hospitals.
He has also set up a campsite in the country's capital, Port-au-Prince, to help provide temporary housing for an estimated 50,000 survivors left homeless by the tremors.
Penn was made a knight in Haiti in July (10) and was also honoured with last year's (10) Hollywood Humanitarian Award - and now his tireless charity work has landed him another accolade, the Producers Guild's 2011 Stanley Kramer Award.
He will be honoured at the PGA's annual awards ceremony, which will be held on 22 January (11) in Los Angeles.
Penn is the first individual to receive the prize, established in 2002 to honour "a motion picture, producer or individual whose achievement or contribution illuminates provocative social issues in an accessible and elevating fashion".
Penn is no stranger to the honour - his movie I AM SAM was the first recipient of the award.
Other previous honorees include: The Great Debaters, An Inconvenient Truth, Hotel Rwanda, Antwone Fisher and last year's (10) Precious: Based on the Novel Push by Sapphire.