The Social Network claimed Best Film, Best Director (David Fincher), Best Adapted Screenplay (Aaron Sorkin) and Best Score (Trent Reznor & Atticus Ross), while Inception took home six prizes, including Best Action Film, Best Visual Effects and Best Sound.
The 16th annual Critics' Choice Movie Awards also honoured Oscar favourites Natalie Portman and Colin Firth with acting awards for their roles in Black Swan and The King's Speech, respectively, while Christian Bale and Melissa Leo claimed the Best Supporting Actor and Actress awards for their roles in The Fighter. The boxing movie also landed the Best Acting Ensemble accolade.
It was a big night for Matt Damon, who was acknowledged by the Broadcast Film Critics Association for his humanitarian efforts.
The True Grit star was the recipient of the fourth annual Joel Siegel Award for Service to the Community largely for founding charity Water.org, with which he hopes to provide drinking water to people in the world's poorest areas.
Damon, who received a standing ovation as he took to the stage at the Hollywood Palladium, used his acceptance speech to urge Americans to donate to his charity.
He said, "These are issues we've known how to solve here for 100 years in our country... Just imagine if we cured AIDS tomorrow and in 100 years, people were still dying of it, three million of them a year. It's just really ridiculous."
The full list of winners is:
Best Picture - The Social Network
Best Actor - Colin Firth (The King's Speech)
Best Actress - Natalie Portman (Black Swan)
Best Supporting Actor - Christian Bale (The Fighter)
Best Supporting Actress - Melissa Leo (The Fighter)
Best Young Actor/Actress - Hailee Steinfeld (True Grit)
Best Acting Ensemble - The Fighter
Best Director - David Fincher (The Social Network)
Best Original Screenplay - David Seidler (The King's Speech)
Best Adapted Screenplay - Aaron Sorkin (The Social Network)
Best Cinematography - Inception
Best Art Direction - Inception
Best Editing - Inception
Best Costume Design - Colleen Atwood (Alice in Wonderland)
Best Make-up - Alice in Wonderland
Best Visual Effects - Inception
Best Sound - Inception
Best Animated Feature - Toy Story 3
Best Action Movie - Inception
Best Comedy - Easy A
Best Picture Made for Television - The Pacific
Best Foreign Language Film - The Girl With the Dragon Tattoo
Best Documentary Feature - Waiting for Superman
Best Song - If I Rise by Dido and A.R. Rahman (127 Hours)
Best Score - The Social Network by Trent Reznor and Atticus Ross