The Silence of the Lambs actor, 73, married 54-year-old Colombian born antiques dealer Stella Arroyave in 2003.
Hopkins has now revealed he was in a terrible state when he was first introduced to Arroyave, but her positive attitude helped him beat his demons.
He tells Britain's Seven magazine, "She met me 10 years ago when I was shut down. Shut down for some years. I didn't feel shut down at the time. I felt I was quite happy. But I was dealing with slight depression. Not trusting anyone. Certainly not trusting women.
"Everyday she wakes up happy. She's very positive about everything. I learned from her just to take life as it comes. So I live my life in non-expectation."