The Slumdog Millionaire moviemaker's production has opened at London's National Theatre, marking the first time he has directed a live show in more than 20 years.
And Boyle has won praise for his latest project, which stars British actors Benedict Cumberbatch and Jonny Lee Miller in alternating roles as Victor Frankenstein and his monster.
The Daily Telegraph's Charles Spencer declares, "The Frankenstein story has become so familiar that it might seem an impossible task to make the old story seem fresh.
"Yet somehow Boyle does just that, constantly creating shocks, spectacular coups de theatre and scenes that tug at the heart."
Libby Purves of The Times adds, "It is a hell of a production. This taut, thrilling play runs to its awful conclusion without an interval, indeed with hardly a moment for breath."
Boyle began his career directing plays before moving into film with the crime thriller Shallow Grave in 1995.