The Legally Blonde beauty walked down the aisle for a second time in a Monique Lhuillier gown with her children, Ava and Deacon, following behind.
The ceremony took place at the star's lavish ranch in Ojai, California and stars including Renee Zellweger, Matthew McConaughey, Tobey Maguire, Robert Downey, Jr., Alyssa Milano, Isla Fisher and Salma Hayek were among the guests.
And Witherspoon ensured it was a wedding her showbiz pals wouldn't forget by releasing 80 white doves after the pair exchanged vows.
The actress was previously married to Ryan Phillippe, the father of her two children. They divorced in 2007 and she went on to date her Rendition co-star Jake Gyllenhaal before striking up a romance with Toth in early 2010.