The actress returned to the stage after a 45-year break to star in the Moises Kaufman play on Broadway and then agreed to lead the cast when the show opened in Los Angeles last month (Feb11).
But the current run proved a little too much for the 73 year old.
Talking to Scissor Sisters star Jake Shears for the current issue of Out magazine, while the show was still running, Fonda revealed she was struggling.
She said, "I don't think I'll do another one (play) again. It just takes over your life.
"I wake up and I feel like a truck ran over me, and then I have to do the play again.
"I'm glad I did it. It was a success. I don't want to do it again because there are too many things in life I like to do."
Fonda's run in the Kaufman play ended earlier this month (Mar11).