In the short film, Crystal and When Harry Met Sally director Rob Reiner try to pitch a sequel to the 1989 movie to three young movie executives.
But in the update, Meg Ryan's character, Sally, is dead! And Helen Mirren plays Crystal's aunt.
The sketch is a true family affair - Crystal's son-in-laws wrote it and it also features his other daughter, Jennifer Crystal.
The skit debuts in the U.S. at midnight on Tuesday (05Apr11).