Like many people, the actress thinks the world as we know it will end on 21 December, 2012 - but it will be more a new beginning than a feared terrible tragedy.
And MacLaine feels sure that all the world's natural disasters, weird weather and our own sense of "speed, speed, speed" is preparing those who want to see and respond to the signs.
Appearing on the Oprah Winfrey Show in America on Monday (11Apr11), the Terms of Endearment star said, "We're coming into an alignment... and it's the first time in 26,000 years that this has occurred... This solar system is on direct alignment with the centre of the galaxy.
"That carries with it a very profound electro-magnetic frequency... and gravitational pull, hence the weather. What does that do to consciousness? What does that do to our sense of reality?
"I know everyone is feeling this sense of speed, speed, speed and they don't know what to do about it. I have a feeling... that the karmic drama of the laws of cause and effect, at the end of the 26,000 years, it is possible that we could be on the threshold of a new beginning. I think what this pressure - this kinda psychic spiritual pressure we're all feeling - is about, what your internal soul is telling you is, 'Get your act together!'"