The Broadway show, created by South Park masterminds Trey Parker and Matt Stone, was named the season's best musical and received trophies for best lyrics, music, director and orchestrations. The quirky and profane musical, about two Mormon missionaries who head to Uganda to promote the faith, is nominated in 14 categories at next month's (Jun11) Tony Awards.
The Drama Desk panel, comprised of theatre journalists and critics, also gave five awards to the revival of Cole Porter musical Anything Goes, including best set design, sound design, musical revival and outstanding actress for Sutton Foster.
A number of Hollywood stars were winners at the ceremony - actress Frances McDormand accepted an acting prize for Good People, while Edie Falco was recognised for The House of Blue Leaves. John Larroquette also went home with a musical acting trophy for How to Succeed in Business Without Really Trying, while John Leguizamo received the outstanding solo performance statue for his one-man show Ghetto Klown.