The actor has been watching the devastation unfold on his computer as he prepares for Thursday's Transformers: Dark of the Moon premiere - and felt compelled to call the KX News broadcast to offer his support to those left homeless - like his own sister.
He told newsman Shaun Sipma, who has lost his property to the floods, "I have been glued to my computer watching you guys... it's difficult to see some of the stuff that's happening there.
"I'm sorry to hear that you... are going to lose your house. It's heartbreaking... It's horrible to see... You see these things happening in other places around the country and around the world.
"Minot is still home to me. I went to elementary, junior high, high school and college in Minot and lived there until I was 22 years old... I'm seeing these places that are in the floods and it's just unbelievable."
Clearly emotional, Duhamel confessed he felt he should be in Minot with his family.
He said, "I feel a little bit silly sitting here in Moscow promoting a movie when I feel I wanna be home... but If there's anybody who's equipped to deal with something like this it's the people of Minot."
Thousands of locals have been evacuated as rising water from surrounding rivers threatens to wash away the town.