He rose to fame playing an oddball alien in TV's Mork & Mindy and went on to take the movie industry by storm, all while juggling a successful stand-up career.
With a number of awards under his belt and a string of high-profile roles in films including Good Morning, Vietnam, Mrs. Doubtfire and Good Will Hunting, Williams has cemented his place as one of Hollywood's most hilarious - and hairiest - men.
To celebrate his 60 years, WENN has compiled 10 fascinating facts about the star:
- Williams' Mork character originally appeared in hit U.S. show Happy Days, before he was given his own spin-off series, Mork & Mindy. The star won the role when producer Garry Marshall asked him to sit down and he responded by resting his head on the seat of a chair.
- He was voted 'least likely to succeed' by classmates during his school days.
- The actor has been married twice. His first marriage was to Valerie Velardi, and he met his second wife, Marsha, when she was nanny to his son, Zak.
- Williams is an avid computer games fan and his daughter Zelda was named after Princess Zelda from The Legend Of Zelda series.
- The comedian studied with late Superman star Christopher Reeve at the Juilliard School in New York and the pair was close friends until Reeve's death in 2004.
- He has been nominated for an Oscar four times but only won once - for Best Supporting Actor in 1997's Good Will Hunting.
- Williams is a keen cyclist, often training with Lance Armstrong, and owns more than 50 bicycles.
- He speaks fluent French.
- The funnyman co-owns a restaurant in San Francisco with Robert De Niro and Francis Ford Coppola.
- The star is an avid philanthropist - he set up the Windfall Foundation, which helps raise money for a variety of charities.