Arquette and Cox split last summer (10) but insisted they were simply on a trial separation while they tried to work out their marriage issues.
However, during a TV interview last month (Jun11), the Scream actor insisted the pair was still best friends but were "definitely not together now".
And it appears the star is focusing on a new lady after he stepped out with Francis' former wife, CBS News showbiz reporter Christina McLarty, who split from the media mogul seven-weeks after marrying him last November (10).
According to People.com, the pair was spotted at the Camp Playboy event at Comic-Con in San Diego, California on Friday (22Jul11), and "danced the night away together". They also hung out together at another event at the convention the following night (23Jul11).