LA Ink, which centres around the star's life and work at West Hollywood's High Voltage Tattoo store, will not return to America's TLC network after its current season draws to a close next month (Sep11).
The show, a spin-off of Miami Ink, first premiered in 2007.
The cancellation follows the breakdown of Von D's relationship with TV mechanic James; Sandra Bullock's cheating ex-husband called off their engagement last month (Jul11).
On a recent episode of LA Ink, Von D was shown unveiling a new tattoo of her then-fiance's face, taken from his high school yearbook.
It was that promo footage which prompted the tattooist to scrap a U.S. TV interview at the last minute and cancel her entire publicity tour for the new series, claiming she wasn't "strong enough" to face the press after she was dumped.