The actress has signed up for the Lupus Foundation of America challenge in Los Angeles and she hopes to raise at least $1,000 (£625) for the organisation, which investigates the cause of the autoimmune disease.
Dushku states on her fundraising page, "I hope you will consider making a secure online donation to help me reach my goal! It's easy to do - just click on the link to support me and complete the donation process. I really appreciate your help! There is hope on the horizon, and with your help we can find better treatments and a cure."
And the star is encouraging her fans to take on the walk too, adding on her Twitter.com page, "Join US! I set a goal to kick some Lupus A**."