The model and actress, who split from the movie stud earlier this summer (11), will preview her 'I'd Rather Go Naked Than Wear Fur' autumn campaign for PETA on the streets of Rodeo Drive on Tuesday (13Sep11).
She's the first Italian to pose naked in the iconic campaign, which has previously featured animal-loving stars like Pamela Anderson, Charlize Theron and Eva Mendes.
Billboards featuring Canalis in her birthday suit and urging fashion lovers not to buy fur products will be unveiled in Milan, Italy for the duration of the upcoming winter style season.
Canalis says, "Don't buy fur. Even a little trim (on) your gloves or your bag or your jackets... You must remember that animals don't have a voice; you must be their voice. Never be afraid to speak up."
Clooney recently showed off his new girlfriend Stacy Keibler at the film festival, where he was promoting new movie The Ides of March.