The Trainspotting star, who is a keen motorcyclist, decided to make a grand entrance for his interview with host Jonathan Ross.
The other guests on the show - Coogan, Barlow and the Take That star's The X Factor co-judge Tulisa Contostavlos - were asked to lie flat on the studio floor next to each other while McGregor clambered onto a motorbike.
The audience members were then left aghast as McGregor sped towards a ramp and jumped over the three stars.
The actor then stripped off his protective biking gear and threw it into the crowd, before taking a seat opposite Ross on the interview sofa.
And it's not the only stunt McGregor carried out on the night - he also shocked viewers as he puckered up in red lipstick, before smooching with the host after asking him if he'd ever kissed a man before.
McGregor asked Ross, "Have you ever kissed a man? Do you want to kiss me now?" The pair then locked lips twice before ending the interview.