The Dark Knight actor will embark on drumming lessons to perfect his transformation as Wilson in Randall Miller's new film The Drummer, which charts the last six years of the rocker's life.
Eckhart, who bears an uncanny resemblance to the Beach Boy, will also sing and play piano in the film, which will start shooting in California early in 2012.
Wilson drowned in Marina del Rey, California in 1983, shortly after he completed work on what was to become his masterpiece album, Pacific Ocean Blue.
Director Miller insists his leading man is the perfect choice to play Wilson, telling WENN, "Aaron is such a finely nuanced actor who is supremely dedicated to getting at the essence of who this rock star was. It is going to be an exciting and emotional journey."
Wilson's children Carl and Jennifer have signed on as co-producers and the film is being made with the family's blessing.
It's not the first time Wilson has been portrayed by an actor on screen - Chris Jacobs played him in Helter Skelter and Bruce Greenwood was Wilson in TV movie Summer Dreams: The Story of the Beach Boys.
More casting details will be announced in the coming weeks, including who will play former Fleetwood Mac star Christine McVie, Wilson's one-time lover.