The auteur shot to fame in the 1970s thanks to the acclaim surrounding his gritty movies Mean Streets and Taxi Driver, but his career took a hit after follow-ups including New York, New York and The King of Comedy failed to make an impact at the box office.
Scorsese's confidence slumped to such a low after his original version of the story of Jesus Christ was scrapped by studio bosses in 1983, he considered turning his back on directing to teach schoolkids.
He tells Britain's The Sun, "After The Last Temptation Of Christ was cancelled I was with (director) Brian De Palma, they had just screened his movie Scarface and the reaction in Hollywood had been hostile.
"I said, 'What should we do?' and he said, 'I don't think we should continue making movies' and I said, 'Probably not, we haven't got a chance here.' So for me the first thing I thought of was teaching. I enjoyed working with younger people and encouraging them. I have worked with many young people."
Scorsese's The Last Temptation of Christ finally hit the big screen in 1988, and earned him an Oscar nomination for Best Director. Meanwhile, De Palma's Scarface went on to garner a huge cult following.