The celebrity couple and their entourage arrived in the European country on Monday and are reportedly getting married in a castle on Lake Bracciano.
Winfrey tells entertainment show Extra, "It's not that I'm not going. It's that they had a limited number of people that they could invite. I was not one of the invitees. That's fine.
"I don't get invited to everyone's wedding. I don't invite them to everything I do. But I wish them the best."
Although the media mogul won't be attending the actual ceremony, she will be sending a wedding present.
She adds, "I have a great deal of regard for their relationship and so I'm trying to think of what to get them.
"I was thinking...I'm easier (to shop for)--you can get me a bubble bath, I'm okay--but I don't know what to give them!"
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