The Bourne Ultimatum star, 37, beat Grey's Anatomy hunk Patrick Dempsey--who is nicknamed Doctor McDreamy on the hit medical series--and Amityville Horror actor Ryan Reynolds to pole position on the annual People magazine hotlist.
But the married Damon, who became a first-time father earlier this year, remains coy about his win.
He tells People, "You've given an aging suburban dad the ego boost of a lifetime."
The magazine cites Damon's "irresistible sense of humor," "rock-solid family man" and "heart-melting humility" for landing him the title.
The top 10 Sexiest Men are as follows:
1. Matt Damon
4. Brad Pitt
5. James McAvoy
6. Johnny Depp
7. Dave Annable
8. Will Smith
10. Shemar Moore
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